Training European Experts in Inflammation:

from the molecular players to animal models and the bedside

The prevalence of chronic inflammatory diseases in western societies is 5-7%, having a major impact on quality of life and healthcare costs. Supporting research on this topic in order to accelerate the pace of anti-inflammatory drug discovery and to have a better understanding of drug actions poses a formidable challenge.

INFLANET is a project involving 21 European partners from the academia and from the private sector that want to joint their efforts to train the next generation of European Experts in Inflammation. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 955576.

Research WorkPackages Training through research Transferable skills training Outreach Activities Recruitement

The training of these future scientific experts of inflammation will be implemented through a combination of individual research projects, collaborative efforts, and interdisciplinary and intersectoral training. It will provide them with a comprehensive understanding of inflammatory processes, allowing to link the underlying genetic, molecular and cellular events to the physiological processes in inflamed tissues. The ultimate goal of INFLANET is to provide innovative solutions for key bottlenecks in the inflammation field.

To this end, we aim to:
(1) Understand how inflammatory signals are detected, integrated by inflammasome platforms, and propagated into tissues
(2) Take omics approaches to elucidate the genetic bases of inflammatory disorders and inform therapeutic strategies
(3) Use cutting-edge intravital imaging strategies in animal models to study molecular and cellular mechanisms of inflammatory processes, and anti-inflammatory drugs actions
(4) Develop original mathematical modelling tools to analyse the wealth of data generated, to inform disease model development, and to provide tools for physicians to understand the pathological basis of inflammatory disorders.

Our unique training approach will unite scientists from very different fields of biology, including structural biologists, bioimagers, immunologists, and geneticists, with mathematicians, programmers and modellers. Moreover, our intersectoral training will foster business thinking and entrepreneurship. Together, INFLANET will deliver a complete curriculum for the next generation inflammation scientists, mastering phenomenological understanding, medical imaging, high content screening and therapeutic strategies.  

Directeur de la publication, Georges Lutfalla.
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LPHI UMR 5235 Laboratory of Pathogen Host Interactions